Mantra 2™ Quantitative Pathology Workstation
Part Number: CLS140089
Easily visualize, quantify and phenotype multiple types of immune cells simultaneously
Introducing Mantra 2™
Akoya is proud to present the next generation of the Mantra family; the Mantra 2™ Quantitative Pathology Workstation. Building on the momentum from the launch of Phenoptics 2.0, this workstation can now be optionally configured to detect up to 8 markers. This is an ideal system for labs just getting started with multiplexing, and also for high-throughput labs looking to streamline their assay development workflow alongside Vectra ® Polaris ™.
The Mantra 2™ Quantitative Pathology Workstation incorporates multispectral imaging technology, image acquisition and analysis with the inForm® software, and can be used with a variety of stains including Akoya’s Opal™ reagent kits.
Traditional methods like flow cytometry and next-generation sequencing allow you to phenotype and quantify immune cells in homogenized samples, but you lose critical spatial information and context. Meanwhile, standard pathological analyses can deliver morphology data but do not allow the analysis of complex phenotypes.
With multispectral imaging, you can phenotype and quantify immune cells from images of FFPE tissue sections, maintaining tissue architecture, cellular spatial relationships and morphological context. This capability available on the Mantra 2™ provides spatial information, allowing for a better understanding of the role and types of immune cells within both the tumor and the tumor microenvironment so that new cancer immunotherapy treatments may be identified and researched.
- Visualizes, analyzes, quantifies and phenotypes immune cells in situ in solid tissues
- Ideal for assay development, freeing up higher throughput systems, such as the Vectra Polaris
- Intuitive workflow that uses LED light source to maximize efficiency for the research pathologist
- Compact system that fits on your benchtop
- Eye-piece for easy visual checking of work as you go
- Automated Brightfield and multispectral fluorescence capabilities
- Optional 9 color multispectral fluorescence upgrade path
- Liquid crystal tunable filter (LCTF) technology
- Phenochart™ whole slide viewer for slide navigation provides context for identification of regions of interest within a digital pathology workflow
- Supports Akoya's Phenoptics™ workflow solution for cancer immunology research
Resources, Events & More
Product Information Bulletin
- Publication: Linch, Stefanie N., et al. "Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice." Proceedings of the National Academy of Sciences 113.3 (2016): E319-E327
- Publication: Miecnik, Bernhard, et al. "The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis." Science translational medicine 8.327 (2016)
- Publication: Esbona, Karla, et al. "COX-2 modulates mammary tumor progression in response to collagen density." Breast Cancer Research 18.1 (2016)
- Publication: Feng, Zipei, et al. "Multispectral Imaging of T and B Cells in Murine Spleen and Tumor." The Journal of Immunology 196.9 (2016): 3943-3950
- Publication: NEJM: Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
- Publication: Novartis Genoptix Shows Multiplexed IHC Test Better Predicts Immunotherapy Response
- Publication: Woods, Katherine, et al. "Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma." Journal for immunotherapy of cancer 4.1 (2016)
- Publication: Huang, Fangjin, et al. "Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET." The Journal of Pathology: Clinical Research (2016)
- Publication: NEJM: PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma
- Publication: Ören, Bilge, et al. "Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis." The Journal of Pathology (2016)
- Poster: Optimization Strategy For Fluorescence Multiplex Immunohistochemistry Tissue Staining
- Poster: Automate Your Complete Cancer Research Workflow with Phenoptics™