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Category: Publication Reviews

Interest in these tumor associated macrophages as targets for cancer therapy has grown rapidly in recent years, especially in combination with conventional chemotherapy, radiotherapy, or immunotherapy. Monotherapies targeting TAMs, however, have shown limited evidence of anti-tumor activity. Read about a new study that, by elucidating the landscape of discreet macrophage niches, provides new insights for development of precision-targeted TAM-directed immunotherapies.
The tumor microenvironment is undeniably complex. Specialized immune cells interact directly and indirectly with tumor cells in a constantly evolving relationship that influences the biology of the tumor. Spatial context is essential to uncovering the mysteries of cell behavior and interactions. Just as individuals may behave differently in cities, suburbs,…