We’ve rebranded some of our products, learn more ›
CODEX® is now PhenoCycler, Phenoptics™ is now Phenolmager.
Introducing PhenoCode Signature Panels
Whether you're developing predictive biomarkers or the next generation of immunotherapies, understanding treatment response, or validating your biomarker studies, PhenoCode™ Signature Panels provide the flexibility to keep pace with the dynamic combination therapy landscape.
What sets PhenoCode Signature Panels Apart?
Relevant Content
Ask the right questions. PhenoCode Signature panels are carefully curated and designed with a selection of protein targets to enable comprehensive analysis of the tumor microenvironment.
Flexibility to Answer More Questions
Bring your plus one! PhenoCode Signature panels are designed to provide flexibility, allowing for easy integration of one additional marker to a 5-plex panel.
Speed Up Spatial Signature Development
From Sample to Data, Faster. PhenoCode Signature panels are optimized and validated to enable the rapid development of spatial signatures by shortening the assay development time by 3X.
Scalable Solution
Seamless integration into existing workflows. The development of Spatial Signatures requires a solution that easily integrates staining, imaging, and analysis using existing workflows, providing scalability without compromising on accuracy and reproducibility.
PhenoCode Signature – How it works
PhenoCode Signature panels were designed to be complementary, enabling mapping of the tumor microenvironment while also providing flexibility to add biomarkers of interest to 5-plex base panels.
Learn about the assay workflow and key advantages these assays provide.
Explore PhenoCode Signature Panels
Featuring a flexible design element, PhenoCode Signature Panels allow for easy integration of a novel checkpoint or immune cell marker into a 5-plex base panel to answer your question of interest. Each panel includes primary antibodies, Opal dyes for high sensitivity detection and assay reagents.
STEP 1
Select a 5-plex base panel to map the TME
STEP 2
Select an antibody to customize your 5-plex base panel
STEP 3
Select the reagents to optimize your PhenoCode Signature Panel
STEP 1
Select a 5-plex base panel
Choose from our menu of complementary 5-plex base panels to map the TME.
STEP 2
Select an antibody to customize your panel
Bring your plus one! Customize your PhenoCode Signature 5-plex base panel by choosing 1 antibody from the list of validated markers below to create your unique 6-plex panel.
Don't see your preferred marker? Select the Antibody Conjugation Kit to use your preferred marker in a PhenoCode Signature Panel.
Catalog #
Name
Anti-Hu Pan-Cytokeratin (AKYP0053)-BX066 for PhenoCode Signature
Anti-Hu CD8 (AKYP0028)-BX026 for PhenoCode Signature
Anti-Hu CD4 (AKYP0048)-BX003 for PhenoCode Signature
Anti-Hu CD3e (AKYP0125)-BX080 for PhenoCode Signature
Anti-Hu CD68 (AKYP0050)-BX015 for PhenoCode Signature
Anti-Hu Ki67 (AKYP0126)-BX047 for PhenoCode Signature
Anti-Hu FoxP3 (AKYP0102)-BX031 for PhenoCode Signature
Anti-Hu CD20 (AKYP0049)-BX064 for PhenoCode Signature
Anti-Hu Granzyme B (AKYP0086)-BX041 for PhenoCode Signature
Anti-Hu PD-1 (AKYP0127)-BX046 for PhenoCode Signature
Anti-Hu PD-L1 (AKYP0103)-BX067 for PhenoCode Signature
Anti-Hu CD45RO (AKYP0059)-BX017 for PhenoCode Signature
Anti-Hu SMA (AKYP0081)-BX013 for PhenoCode Signature
Antibody Conjugation Kit for PhenoCode Signature
STEP 3
Detect your +1 Antibody with Opal 520
Catalog #
Name
Opal 520 Reagent Pack
Need to configure your own PhenoCode Signature Panel?
Mix and match using our selection of PhenoCode Signature antibodies and the reagents below.
Catalog #
Name
Staining Kit for PhenoCode Signature
Opal 480 Reagent Pack
Opal 520 Reagent Pack
Opal 570 Reagent Pack
Opal 620 Reagent Pack
Opal 690 Reagent Pack
Opal 780 Reagent Pack
10X Spectral DAPI
Explore Opals and Other Staining Essentials
Opal Reagent Packs
Opals Reagent Packs include an Opal fluorophore dye packaged with DMSO for dye reconstitution. The Opal system provides TSA-based signal amplification to detect co-localized biomarkers at sub-cellular sensitivity.
Catalog #
Name
Opal 480 Reagent Pack
Opal 520 Reagent Pack
Opal 540 Reagent Pack
Opal 570 Reagent Pack
Opal 620 Reagent Pack
Opal 650 Reagent Pack
Opal 690 Reagent Pack
Opal 780 Reagent Pack
10X Spectral DAPI
Opal Detection Kits
Opal Multiplex Detection Kits are offered for both automated and manual staining workflows. Provide your own primary antibodies to develop a novel multiplexed, fluorescent IHC panel. Image using PhenoImager® Fusion or PhenoImager™ HT (formerly Vectra Polaris) imaging systems, part of Akoya's end-to-end solution for unparalleled quantitative data in translational research.
Catalog #
Name
Opal 6-Plex Detection Kit - for Whole Slide Imaging
Opal 6-Plex Manual Detection Kit - for Whole Slide Imaging
Opal 6-Plex Detection Kit
Opal 6-Plex Manual Detection Kit
Opal 3-Plex Detection Kit
Opal 3-Plex Manual Detection Kit
Opal 3-Plex Anti-Rb Detection Kit
Opal 3-Plex anti-Rabbit Manual Detection Kit
Opal Anti-Rb HRP Kit
Opal Anti-Ms + Rb HRP Kit
Staining Essentials
Opals Reagent Packs include an Opal fluorophore dye packaged with DMSO for dye reconstitution. The Opal system provides TSA-based signal amplification to detect co-localized biomarkers at sub-cellular sensitivity.
Catalog #
Name
1X Antibody Diluent / Block
1X Plus Automation Amplification Diluent
1X Plus Manual Amplification Diluent
10X AR6 Buffer
10X AR9 Buffer
TSA Reagents
Tyramide Signal Amplification (TSA™) increases staining sensitivity by 2-3 logs over standard fluorescent methods. Resolution and dynamic range are maintained, allowing for reduced consumption of primary antibodies.
Catalog #
Name
TSA Plus Biotin
TSA Plus DIG
TSA Plus Cyanine 3
TSA Plus Cyanine 3.5
TSA Plus Cyanine 5
TSA Plus Fluorescein
TSA Plus TMR
