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PhenoCode Signature T Cell Status Human Protein Panel
As the major population of immune cells within the tumor microenvironment (TME), T cells are a driver of anti-tumor immunity. T cell exhaustion and the presence of immunosuppressive cells can contribute to an immunosuppressive TME. PhenoCode™ Signature T Cell Status Panel (CD8, CD4, CD20, FoxP3, PD-1) allows for identification of distinct T Cell subsets and effector functionality status. Map additional phenotypes by adding a 6th marker to the panel from the antibody list below or add your own marker of interest by using the Antibody Conjugation Kit to barcode your antibody of choice.
Step 1: Order Panel
Catalog #
Product
Size
PCSPP005
PhenoCode Signature T Cell Status Human Protein Panel
(CD8, CD4, CD20, FoxP3, PD-1)
(CD8, CD4, CD20, FoxP3, PD-1)
Up to 20 Slides
Step 2: Choose 1 Antibody
Catalog #
Product
Size
S6501000
Anti-Hu Pan-Cytokeratin (AKYP0053)-BX066 for PhenoCode Signature
Up to 20 Slides
S6501003
Anti-Hu CD3e (AKYP0125)-BX080 for PhenoCode Signature
Up to 20 Slides
S6501004
Anti-Hu CD68 (AKYP0050)-BX015 for PhenoCode Signature
Up to 20 Slides
S6501005
Anti-Hu CD163 (AKYP0114)-BX069 for PhenoCode Signature
Up to 20 Slides
S6501006
Anti-Hu Ki67 (AKYP0126)-BX047 for PhenoCode Signature
Up to 20 Slides
S6501009
Anti-Hu Granzyme B (AKYP0086)-BX041 for PhenoCode Signature
Up to 20 Slides
S6501011
Anti-Hu PD-L1 (AKYP0103)-BX067 for PhenoCode Signature
Up to 20 Slides
S6501012
Anti-Hu CD45RO (AKYP0059)-BX017 for PhenoCode Signature
Up to 20 Slides
S6501013
Anti-Hu SMA (AKYP0081)-BX013 for PhenoCode Signature
Up to 20 Slides
OR Barcode your own Antibody
Catalog #
Product
Size
PCSP0200
Antibody Conjugation Kit for PhenoCode Signature
Up to 20 Slides
Step 3: Detect your +1 Antibody with Opal 520
Catalog #
Product
Size
FP1487001KT
Opal 520 Reagent Pack
Up to 50 Slides
PhenoCode Signature panels are validated for the PhenoImager® platform which integrates staining, imaging, and analysis using well-established workflows providing accuracy and reproducibility. Featuring a flexible design element, PhenoCode Signature panels allow for the easy integration of a novel checkpoint or immune cell marker into a 5-plex base panel.
PhenoCode Signature T Cell Status Human Protein Panel contains:
- 5 Primary antibodies targeting CD8, CD4, CD20, FoxP3, PD-1
- 5 PhenoCode Signature Detectors
- 5 Opal dyes + DMSO for signal amplification: Opal 480, Opal 570, Opal 620, Opal 690, Opal 780 + TSA-DIG
- 10X Spectral DAPI
- 1X Plus Automation Amplification Diluent
- PhenoCode Signature Diluent
- 1X Antibody Diluent/Block
- PhenoCode Signature Blocker 1
- PhenoCode Signature Blocker 5
- N Blocker
- J Blocker
- S Blocker
PhenoCode Signature T Cell Status Human Protein Panel
Comprehnsive Document Lisitng Kit Components, Material & Methods to run the T Cell Status Human Protein Panel
Technical Data Sheet & Protocol
Six Plex for Success
Strategies for Developing Clinically Useful Spatial Signature Biomarkers
White Paper
Decoding the Science of Response to Cancer Therapy
Benefits of PhenoCode Signature Panels and Case Study
Application Note
A Comprehensive Approach to Immunotherapy Response Prediction: Unlocking Spatial Signatures with Complementary PhenoCode Signature Panels
Poster
The Potential Predictive Role of Spatial Phenotyping in Non-small Cell Lung Cancer (NSCLC)
Poster
