Poster Presentation
The mutational landscape defines the proteome and spatial organization of tumor, stroma, and immune cells in ovarian cancer
Authors: Kruttika Dabke1, Bassem Ben Cheikh2, Nicole Gull1, Amisha Dhawan2, Katrina Evans2, Simion Kreimer1, Pei-Chen Peng1, Nathan Ing1, Kate Lawrenson1, Bobbie Rimel1, Beth Karlan3, Simon Knott1, Simon Gayther1, Sarah Parker1, Michelle Jones1
1. Cedars Sinai Medical Center, Los Angeles, California, USA; 2. Akoya Biosciences, Menlo Park, California, USA; 3. David Geffen School of Medicine at UCLA, Los Angeles, CA
See how Kruttika Dabke, PhD (Cedars Sinai Medical Center) and her team used a 26-plex panel on the PhenoCycler-Fusion platform to profile 36 million cells and map the tumor immune landscape of high-grade serous ovarian cancer (HGSOC), exploring how the HGSOC immune landscape is rearranged after treatment and how that is influenced by homologous recombination repair (HRR) mutations.
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