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A Single-Cell and Spatially-Resolved Atlas of the Human and Murine Oral Cavity
Webinar | Tuesday, October 22, 2024
The oral cavity serves as the gateway to both the respiratory and digestive tracts and shares structural features with the skin. Despite its specialized niches—labial and buccal mucosae, salivary glands, periodontium, palate, and tongue—our understanding of cellular heterogeneity, communication, and spatial patterns within these regions remains limited.
In this webinar, Dr. Inês Sequeira (Queen Mary University of London) will discuss how multi-omic spatial technologies have been used to build the first Oral Cell Atlas, for both mouse and human tissues. Key findings include 1) Shared and unique cell subpopulations across oral niches and other epithelia, suggesting niche-specific immune residency and 2) A unique fibroblast subpopulation in the buccal mucosa that may explain its scarless healing compared to skin. This comprehensive atlas offers new insights into oral tissue heterogeneity and serves as a valuable resource for research and clinical applications.
Learning Objectives:
- Understand different and complementary outputs of single cell and spatial omics.
- Understand the cellular heterogeneity of skin and oral tissues.
Video
Speaker
Dr. Inês Sequeira, MSc PhD
Senior Lecturer in Oral and Skin Biology, Deputy Director of Research, Institute of Dentistry at Queen Mary University of London
Biography
Dr Inês Sequeira, Group Leader and Associate Professor at Queen Mary University of London, has dedicated her research career to studying skin and oral epithelia homeostasis, wound healing and cancer. Her team focuses on understanding the scarless potential of the oral mucosa when compared to skin, and in studying the heterogeneity and clonal evolution of oral cancer.
She is a coordinator of the Human Cell Atlas Oral and Craniofacial Network, where they use state-of-art computational tools and single cell transcriptomics and spatial proteomics and transcriptomics to dissect the molecular and cellular heterogeneity of the oral tissues in health and disease.
