High-grade gliomas are a group of malignant brain tumors with a dismal prognosis and exceptionally high intra- and intertumoral heterogeneity. Identifying complex phenotypes in these tissues enables us to better understand the cellular hierarchies and the overall tumor architecture.

 

Leveraging novel multiplex phenotyping technologies coupled with advanced disease models based on human pluripotent stem cells (iPSC) and primary brain tumor cells can provide new insights into tumorigenesis, tumor evolution and targetable vulnerabilities within these tumors.

 

This webcast will describe use of these advanced technologies and the resulting imaging data to build more representative preclinical models for rapid therapy identification and translation.