Exploring Biology Through a New Lens: A Spatial Approach

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CODEX® is now PhenoCycler, Phenoptics™ is now Phenolmager.

Exploring Biology Through a New Lens: A Spatial Approach

Original Air Date: December 9, 2021

Transformative technology doesn’t come along often, so when it does, scientists take notice. Spatial biology has rapidly changed how investigators study diverse cellular landscapes across multiple dimensions. This has allowed researchers to study cells in context with their localized environment—affording them novel biological insights. A thorough understanding of complex spatial host-disease interactions in situ is necessary to develop effective preventative measures and therapeutic strategies. In this webinar, originally broadcast by Genetic Engineering & Biotechnology News (GEN), Dr. Sizun Jiang shares data from a clinical cohort of cutaneous T cell lymphoma (CTCL) patients, in which he and his laboratory show how to robustly titrate and validate antibodies with the highly multiplexing capabilities of PhenoCycler^™ (formerly CODEX^®). Dr. Jiang will also describe how his findings can be extended to understanding immune-tumor interactions for a better understanding of immunotherapy responses and strategies in CTCL. Dr. Niro Ramachandran sets the stage for Dr. Jiang’s talk by discussing the need for new techniques that take full advantage of complementary technologies to unravel complex biological mechanisms in healthy and diseased tissues. In addition, he provides an overview of Akoya’s Imaging Innovators (I²) network, a first-of-its-kind collaboration of pioneering scientists from world-class research organizations with ambitions to advance the field of spatial biology.

You will learn

Proven techniques for stringent and robust validation of markers for multiplexed imaging technologies such as PhenoCycler.
Computational strategies for analysis of multiplexed PhenoCycler images
How to design and incorporate multiplexed imaging experiments into current projects

Video

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Speaker

Sizun Jiang, PhD

Principal Investigator, Center for Virology and Vaccine Research
Beth Israel Deaconess Medical Center, Harvard Medical School

Biography

Sizun Jiang, PhD, is a principal investigator at the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, and associate professor at Harvard Medical School. Sizun received his PhD from Harvard University, where he studied under Prof. Elliott Kieff to uncover complex host-pathogen chromatin interactions involved in viral-driven lymphomagenesis. During his postdoctoral studies with spatial biology pioneer Prof. Garry Nolan at Stanford University, he focused on developing new spatial technology tools and applications to better interrogate biological systems. Sizun is a new investigator in the Imaging Innovators Network sponsored by Akoya Bioiosciences.

Niro Ramachandran, PhD

Chief Business Officer,
Akoya Biosciences

Biography

Niro Ramachandran, PhD, is Chief Business Officer at Akoya Biosciences. Niro has had his finger on the pulse of the spatial biology market since its inception and has a deep understanding of the unique technical challenges of spatial biology. At Akoya, Niro is responsible for developing a robust roadmap and commercialization strategy for Akoya’s platforms. He received his PhD from University of Windsor, and completed his post doctorate work at the Harvard Institute of Proteomics, Harvard University.

CODEX® is now PhenoCycler, Phenoptics™ is now Phenolmager.