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Exploring Spatial Omics: From Laboratory Research to Oncology Practice
Webinar | Tuesday, June 21, 2024
Join our webinar to explore cutting-edge advancements in precision oncology for treating metastatic recurrent Head & Neck Oropharyngeal Squamous Cell Carcinomas (OPSCCs). Despite immune checkpoint inhibitors being available, less than 20% of patients respond. Utilizing spatial transcriptomics and in-situ multiprotein detection, our speakers will analyze tumors from a patient sensitive to pembrolizumab and lenvatinib and those with reduced lenvatinib sensitivity. Our speakers identified distinct tumor regions and key druggable targets, leading to a novel cell deconvolution method that surpasses existing techniques. Discover how these findings can enhance treatment personalization and improve outcomes in advanced cancer care.
Video
Speaker
Jazmina Gonzalez Cruz, PhD.
Senior Research Fellow
The University of Queensland
Diamantina Institute Faculty of Medicine
The University of Queensland
Diamantina Institute Faculty of Medicine
Biography
Dr. Cruz is a renowned research scientist specializing in molecular and cellular biology, with a focus on T cell activation, regulation, and cancer immunology. She earned her PhD with honors in 2011 from the National Centre of Biotechnology in Spain, studying immune evasion strategies of Coronaviruses. She completed a postdoctoral fellowship at the Heinrich Pette Institute in Germany, supported by a Bayer-Alexander Von Humboldt Foundation grant. Currently, Dr. Cruz leads the Cancer Immunology and Therapy group at the Translational Research Institute, utilizing high-throughput technologies to investigate immune suppression in epithelial cancers, aiming to develop therapeutic strategies to support immune function in patients.
Quan Nguyen, PhD.
Group Leader
Genomics and Medicine Learning Lab
QIMR Berghofer Medicine Research Institiute
Genomics and Medicine Learning Lab
QIMR Berghofer Medicine Research Institiute
Biography
Dr. Quan Nguyen leads the Genomics and Machine Learning (GML) lab at the Institute for Molecular Bioscience, University of Queensland. His research focuses on neuroinflammation and cancer-immune cells, utilizing single-cell resolution and spatial tissue context to understand gene and cell regulators in cancer and neuronal ecosystems. Dr. Nguyen integrates single-cell sequencing with tissue imaging to uncover links between cellular genotypes and disease phenotypes. He has held prestigious fellowships, including an Australian Research Council DECRA fellowship and a National Health and Medical Research Council leadership fellowship. Dr. Nguyen has published extensively and developed several open-source tools for single-cell data analysis.
